There is no street value for Dextromethorphan (DXM), since it is an over-the-counter cough suppressant commonly found in cold medications. DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations.
NMDA receptor antagonists
Drug subcultures are examples of countercultures that are primarily defined by recreational drug use.
Drug subcultures are groups of people united by a common understanding of the meaning and value (good or otherwise) of the incorporation into one's life of the drug in question. Such unity can take many forms, from friends who take the drug together, possibly obeying certain rules of etiquette, groups banding together to help each other obtain drugs and avoid arrest to full-scale political movements for the reform of drug laws. The sum of these parts can be considered an individual drug's "culture".
Recreational use of dextromethorphan
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the -aspartateD-Methyl-N receptor (NMDAR). They are used as anesthesia for animals and for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. There is evidence that NMDA receptor antagonists can cause a certain type of neurotoxicity or brain damage referred to as Olney's Lesions in rodents, although such damage has never been conclusively observed in primates like humans. However, in adolescent cynomolgus monkeys that were injected daily with the non-competitive NMDA antagonist, ketamine, there were some definite neurologic deficits observed.
Several synthetic opioids function additionally as NMDAR-antagonists, such as Meperidine, Methadone, Dextropropoxyphene, Tramadol and Ketobemidone.
Dextromethorphan (DXM), a common active ingredient found in many over-the-counter cough suppressant cold medicines, is used as a recreational drug for its dissociative effects. It has almost no psychoactive effects at medically recommended doses. Dextromethorphan has powerful dissociative properties when administered in doses well above those considered therapeutic for cough suppression. Recreational use of DXM is sometimes referred to in slang form as robo-tripping, whose prefix derives from the Robitussin brand name, or Triple Cs, which derives from the Coricidin brand (the pills were printed with "CCC"). This stands for Coricidin Cough and Cold.
In over the counter formulations, DXM is often combined with acetaminophen (paracetamol, APAP) to relieve pain and to prevent recreational use; however, to achieve DXM's dissociative effects, the maximum daily therapeutic dose of 4000 mg of APAP is often exceeded, potentially causing acute or chronic liver failure, making abuse and subsequent tolerance of products which contain both DXM and APAP potentially fatal.
A cough medicine (or linctus, when in syrup form) is a medicinal drug used in an attempt to treat coughing and related conditions. For dry coughs, treatment with cough suppressants (antitussives) may be attempted to suppress the body's urge to cough. However, in productive coughs (coughs that produce phlegm), treatment is instead attempted with expectorants (typically guaifenesin, in most commercial medications) in an attempt to loosen mucus from the respiratory tract.
There is no good evidence for or against the use of these medications in those with a cough. Even though they are used by 10% of American children weekly, they are not recommended in children 6 years of age or younger because of lack of evidence showing effect and concerns of harm.
Dissociatives are a class of hallucinogen, which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression]citation needed[, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.]citation needed[
The effects of dissociatives can include sensory dissociation, hallucinations, mania, catalepsy, analgesia and amnesia. The characteristic features of dissociative anesthesia were described as catalepsy, amnesia and analgesia. According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment." Bonta (2004) described dissociative anaesthesia as "... a peculiar anaesthetic state in which marked sensory loss and analgesia as well as amnesia is not accompanied by actual loss of consciousness." Both Pender (1970) and Johnstone et al. (1959) reported that patients under anesthesia due to either ketamine or phencyclidine were prone to purposeless movements and had hallucinations (or "dreams") during and after anesthesia. Some patients found the hallucinations euphoric while others found them disturbing.
Health Medical Pharma
A social issue (also called a social problem, societal ill, social ill, or social situation) is an issue that relates to society's perception of a person's life, moral character, occupation, etc.. Different cultures have different perceptions and what may be "normal" behavior in one society may be a significant social issue in another society. Social issues are distinguished from economic issues. Some issues have both social and economic aspects, such as immigration. There are also issues that don't fall into either category, such as wars.
Thomas Paine, in Rights of Man and Common Sense, addresses man's duty to "allow the same rights to others as we allow ourselves". The failure to do so causes the birth of a social issue.
visual and auditory hallucinations
Health Medical Pharma
Science of drugs including their origin, composition, pharmacokinetics,
pharmacodynamics, therapeutic use, and toxicology.
Pharmacology (from Greek φάρμακον, pharmakon, "poison" in classic Greek; "drug" in modern Greek; and -λογία, -logia "study of", "knowledge of") is the branch of medicine and biology concerned with the study of drug action, where a drug can be broadly defined as any man-made, natural, or endogenous (within the body) molecule which exerts a biochemical and/or physiological effect on the cell, tissue, organ, or organism. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals.