The Biggest Loser is a reality television show which started in the U.S. in 2004. The show centers on overweight contestants attempting to lose the most weight and to fight for a cash prize. There are different variations of The Biggest Loser around the world. Each country has made its own adaptation to the show; however, the contestants always have the same goal: to lose the highest percentage of weight (or most weight) to become the Biggest Loser.
A similar programme, Operation: Transformation, airs on Irish television on RTE One, however it does not have a competitive format.
The endocrine system is referring to the collection of cells, glands, and tissues of an organism that secrete hormones directly into the bloodstream (some of which are transported along nerve tracts]citation needed[) to control the organisms' physiological and behavioral activities. The endocrine system is in contrast to the exocrine system, which secretes its chemicals using ducts. The word endocrine derives from the Greek words "endo" meaning inside, within, and "crinis" for secrete. The endocrine system is an information signal system like the nervous system, yet its effects and mechanism are classifiably different. The endocrine system's effects are slow to initiate, and prolonged in their response, lasting from a few hours up to weeks. The nervous system sends information very quickly, and responses are generally short lived. Hormones are substances (chemical mediators) released from endocrine tissue into the bloodstream where they travel to target tissue and generate a response. Hormones regulate various human functions, including metabolism, growth and development, tissue function, sleep, and mood. The field of study dealing with the endocrine system and its disorders is endocrinology, a branch of internal medicine.
Features of endocrine glands are, in general, their ductless nature, their vascularity, and usually the presence of intracellular vacuoles or granules storing their hormones. In contrast, exocrine glands, such as salivary glands, sweat glands, and glands within the gastrointestinal tract, tend to be much less vascular and have ducts or a hollow lumen.
The human skeleton is composed of 300 bones at birth and by the time adulthood is reached, some bones have fused together to give a total of 206 bones in the body. The bone mass in the skeleton reaches maximum density around age 30. The human skeleton can be divided into the axial skeleton and the appendicular skeleton. The axial skeleton is formed by the vertebral column, the rib cage and the skull. The appendicular skeleton, which is attached to the axial skeleton, is formed by the pectoral girdles, the pelvic girdle and the bones of the upper and lower limbs.
The human skeleton serves six major functions; support, movement, protection, production of blood cells, storage of ions and endocrine regulation.