DNA Replication and Causes of Mutation
After replication, mismatch repair reduces the final error rate even further. Incorrectly paired nucleotides cause deformities in the secondary structure of the final DNA molecule. During mismatch repair, enzymes recognize and fix these deformities by ...
Researchers Discover What Happens to Helicase Enzyme Before it Encircles the DNA
Researchers working in Speck and Stillman's labs used tools of molecular biology ... ring structure to keep DNA polymerase enzymes from falling off the DNA while synthesizing new strands to complete the replication process. "Both of these complexes were ...
DNA 'replication fork' reconstituted for the first time
"As a research tool, our model could allow scientists to better understand what occurs in DNA replication, and what goes wrong in disease states," O'Donnell says. To create his replication fork model, O'Donnell used enzymes from yeast. Like human cells ...
Study identifies enzymes that help fix cancer-causing DNA defects
Yen1 is the first Cdc14 substrate involved in DNA repair to be identified. Hall said the remarkable similarity of these enzymes in yeast and humans makes it likely that this method could be used to identify targets of Cdc14 in humans as well. "Despite ...
DNA Replication Enzyme Might Be Cancer Drug Target
An enzyme essential for DNA replication and repair in humans works in a way that ... effort to grow crystals of the human FEN1 protein bound to DNA. The team then used X-ray crystallography to determine the atomic structure of the complex.