Question:

What disease does Michael J. Fox have?

Answer:

Michael J. Fox battles with Parkinson's disease. Fox was diagnosed with the degenerative brain disease back in 1991. AnswerParty again!

More Info:

Parkinson's disease (PD also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, whereas depression is the most common psychiatric symptom. Other symptoms include sensory, sleep and emotional problems. Parkinson's disease is more common in older people, with most cases occurring after the age of 50.

The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". Parkinson's disease is often defined as a parkinsonian syndrome that is idiopathic (having no known cause), although some atypical cases have a genetic origin. Many risk and protective factors have been investigated: the clearest evidence is for an increased risk of PD in people exposed to certain pesticides and a reduced risk in tobacco smokers. The pathology of the disease is characterized by the accumulation of a protein called alpha-synuclein into inclusions called Lewy bodies in neurons, and from insufficient formation and activity of dopamine produced in certain neurons within parts of the midbrain. Lewy bodies are the pathological hallmark of the idiopathic disorder, and the distribution of the Lewy bodies throughout the Parkinsonian brain varies from one individual to another. The anatomical distribution of the Lewy bodies is often directly related to the expression and degree of the clinical symptoms of each individual. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging being used for confirmation.

Michael J. Fox, OC (born Michael Andrew Fox; June 9, 1961) is a Canadian American actor, author, producer, activist and voice-over artist. With a film and television career spanning from the late 1970s, Fox's roles have included Marty McFly from the trilogyBack to the Future (1985–1990); Alex P. Keaton from Family Ties (1982–1989) for which he won three Emmy Awards and a Golden Globe Award; Mike Flaherty from Spin City (1996–2000), for which he won an Emmy, three Golden Globes, and two Screen Actors Guild Awards; and Private Max Eriksson in the Brian De Palma film Casualties of War.

Fox's middle initial "J" does not stand for anything. His birth name is Michael Andrew Fox but when he registered for the Screen Actors Guild, the name "Michael Fox" was already taken. Fox said he did not want to register "Michael A. Fox" because it presented a play on words, and that he was paying homage to actor Michael J. Pollard.

degenerative brain disease disease Health Nationality

Clinical research is a branch of medical science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease. Clinical Research is different than clinical practice. In clinical practice one uses established treatments, while in clinical research evidence is collected to establish a treatment.

The term clinical research refers to the entire bibliography of a drug/device/biologic, in fact any test article from its inception in the lab to its introduction to the consumer market and beyond. Once the promising candidate or the molecule is identified in the lab, it is subjected to pre-clinical studies or animal studies where different aspects of the test article (including its safety toxicity if applicable and efficacy, if possible at this early stage) are studied.

The Michael J. Fox Foundation for Parkinson's Research is dedicated to finding a cure for Parkinson's disease (PD) through an aggressively funded research agenda and to ensure the development of improved therapies for those living with Parkinson's today. Established by actor Michael J. Fox in 2000, the Foundation has since become the largest nonprofit funder of Parkinson's disease research in the world, investing more than $350 million in research to date. The Foundation's proactive approach to advancing PD science has made it "the most credible voice on Parkinson's research in the world". In 2010 the Fox foundation launched the first large-scale clinical study on evolution biomarkers of the disease at a cost of 45 million dollars over 5 years.

Memory disorder is the result of damage to neuroanatomical structures that hinders the storage, retention and recollection of memories. Memory disorders can be progressive, including Alzheimer's disease, or they can be immediate including disorders resulting from head injury.

Parkinson's disease (PD also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later, thinking and behavioral problems may arise, with dementia commonly occurring in the advanced stages of the disease, whereas depression is the most common psychiatric symptom. Other symptoms include sensory, sleep and emotional problems. Parkinson's disease is more common in older people, with most cases occurring after the age of 50.

The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". Parkinson's disease is often defined as a parkinsonian syndrome that is idiopathic (having no known cause), although some atypical cases have a genetic origin. Many risk and protective factors have been investigated: the clearest evidence is for an increased risk of PD in people exposed to certain pesticides and a reduced risk in tobacco smokers. The pathology of the disease is characterized by the accumulation of a protein called alpha-synuclein into inclusions called Lewy bodies in neurons, and from insufficient formation and activity of dopamine produced in certain neurons within parts of the midbrain. Lewy bodies are the pathological hallmark of the idiopathic disorder, and the distribution of the Lewy bodies throughout the Parkinsonian brain varies from one individual to another. The anatomical distribution of the Lewy bodies is often directly related to the expression and degree of the clinical symptoms of each individual. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging being used for confirmation.

Medicine

Michael J. Fox, OC (born Michael Andrew Fox; June 9, 1961) is a Canadian American actor, author, producer, activist and voice-over artist. With a film and television career spanning from the late 1970s, Fox's roles have included Marty McFly from the trilogyBack to the Future (1985–1990); Alex P. Keaton from Family Ties (1982–1989) for which he won three Emmy Awards and a Golden Globe Award; Mike Flaherty from Spin City (1996–2000), for which he won an Emmy, three Golden Globes, and two Screen Actors Guild Awards; and Private Max Eriksson in the Brian De Palma film Casualties of War.

Fox's middle initial "J" does not stand for anything. His birth name is Michael Andrew Fox but when he registered for the Screen Actors Guild, the name "Michael Fox" was already taken. Fox said he did not want to register "Michael A. Fox" because it presented a play on words, and that he was paying homage to actor Michael J. Pollard.

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