Question:

What disease does brick, from the middle, have?

Answer:

Atticus Shaffer as Brick Heck, youngest child, has osteogenesis imperfecta, also known as brittle bone disease.

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Atticus Shaffer

Atticus Ronald Shaffer (born June 19, 1998) is an American actor, best known for portraying Matty Newton in the 2009 film The Unborn and Brick Heck in the ABC sitcom The Middle.

Anatomy

Osteogenesis imperfecta (OI and sometimes known as brittle bone disease, or "Lobstein syndrome") is a congenital bone disorder characterized by brittle bones that are prone to fracture. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. Eight types of OI can be distinguished. Most cases are caused by mutations in the COL1A1 and COL1A2 genes.

Diagnosis of OI is based on the clinical features and may be confirmed by collagen or DNA testing. There is no cure for OI. Treatment is aimed at increasing overall bone strength to prevent fracture and maintain mobility. The incidence of OI is estimated to be one per 20,000 live births.

Biology

The human skeleton is composed of 300 bones at birth and by the time adulthood is reached, some bones have fused together to give a total of 206 bones in the body. The bone mass in the skeleton reaches maximum density around age 30. The human skeleton can be divided into the axial skeleton and the appendicular skeleton. The axial skeleton is formed by the vertebral column, the rib cage and the skull. The appendicular skeleton, which is attached to the axial skeleton, is formed by the pectoral girdles, the pelvic girdle and the bones of the upper and lower limbs.

The human skeleton serves six major functions; support, movement, protection, production of blood cells, storage of ions and endocrine regulation.

The Middle Ossification Bone

1Q7D, 2LLP, 3EJH, 3GXE

Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage.

Madge Bester (born 26 April 1963) is the world's former shortest living woman. From South Africa, she measures 2 ft 1.5 in (65 cm) in height which was measured in 1991. Bester has osteogenesis imperfecta, which is characterized by brittle bones, and uses a wheelchair. She has been a campaigner for disabled rights, holding a 1998 press conference on the issue accompanied by Lin Yih-Chih, the world's smallest man.

Bester lives in a retirement village in Bloemfontein. Her mother Winnie, who died in 2001, also suffered from osteogenesis imperfecta and measured only 70 cm.

Health Medical Pharma

The Middle is an American sitcom television series, airing on ABC since September 30, 2009. The series features Frances "Frankie" Heck (Patricia Heaton), a working-class, Midwestern woman and her husband Mike Heck (Neil Flynn), who reside in the small fictional town of Orson, Indiana. They are the parents of three children, Axl (Charlie McDermott), Sue (Eden Sher), and Brick (Atticus Shaffer). The show is created by former How I Met Your Mother executive producers Eileen Heisler and DeAnn Heline.

Osteogenesis imperfecta (OI and sometimes known as brittle bone disease, or "Lobstein syndrome") is a congenital bone disorder characterized by brittle bones that are prone to fracture. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. Eight types of OI can be distinguished. Most cases are caused by mutations in the COL1A1 and COL1A2 genes.

Diagnosis of OI is based on the clinical features and may be confirmed by collagen or DNA testing. There is no cure for OI. Treatment is aimed at increasing overall bone strength to prevent fracture and maintain mobility. The incidence of OI is estimated to be one per 20,000 live births.

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