4000 mg Tylenol a day can cause liver failure when taken on a regular basis and in people who drink alcohol even occasionally.
Median lethal dose
Liver failure is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology. Two forms are recognised, acute and chronic.
Acute liver failure is defined as "the rapid development of hepatocellular dysfunction, specifically coagulopathy and mental status changes (encephalopathy) in a patient without known prior liver disease".:1557
Chicago Tylenol murders
An alcoholic beverage is a drink that contains ethanol. Alcoholic beverages are divided into three general classes for taxation and regulation of production: beers, wines, and spirits (distilled beverages). They are legally consumed in most countries around the world. More than 100 countries have laws regulating their production, sale, and consumption. Beer is the third most popular drink in the world, after water and tea.
Alcoholic beverages have been consumed by humans since the Neolithic era; the earliest evidence of alcohol was discovered in Jiahu, dating from 7000–6600 BC. The production and consumption of alcohol occurs in most cultures of the world, from hunter-gatherer peoples to nation-states.
Health Medical Pharma
The Chicago Tylenol murders occurred when seven people died after taking pain-relief medicine capsules that had been poisoned. The poisonings, code-named TYMURS by the Federal Bureau of Investigation, took place in September and early October 1982, in the Chicago area of the United States.
These poisonings involved Extra-Strength Tylenol capsules, manufactured by McNeil Consumer Healthcare, which had been laced with potassium cyanide. The incidents led to reforms in the packaging of over-the-counter substances and to federal anti-tampering laws. The case remains unsolved and no suspects have been charged. A $100,000 reward offered by Johnson & Johnson, McNeil's parent company, for the capture and conviction of the "Tylenol Killer" has never been claimed.