Has Peyton Manning and Eli Manning ever played in a NFL game against each other?


The Manning brothers -- Peyton of the Colts and Eli of the Giants -- will play opposite each other for the first time to open NBC's Sunday Night football schedule. That game is Sept. 10 (8:15 p.m. ET) at the Meadowlands.

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National Football League Eli Manning Peyton Manning Eli Manning Peyton Manning Indianapolis Colts Giants Stadium Indianapolis Colts season National Football League American football in the United States Super Bowl MVPs NFL Sunday Night NFL NBC New York Giants season Sports

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