Trace amounts of nicotine can be detected in blood and urine for several hours but should not be detectable in blood or urine after 48 hours. However, COTININE, which is a metabolite of nicotine can be detected in blood or urine for up to 7 days.
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs).
Examples include: Pyridines
Nicotine poisoning describes the symptoms of the toxic effects of consuming nicotine, which can potentially be deadly. Historically, most cases of nicotine poisoning have been the result of use of nicotine as an insecticide. More recent cases of poisoning typically appear to be due to accidental ingestion of tobacco or tobacco products or ingestion of nicotine containing plants.
The probable lethal dose of nicotine has been reported as between 40 and 60 milligrams (the total amount in about 2 cigarettes if all of the nicotine was absorbed) in adults and about 1 mg/kg in children (less than 1 cigarette) . Children may become ill following ingestion of one cigarette, ingestion of more than this may cause a child to become severely ill. In some cases children have become poisoned by topical medicinal creams which contain nicotine.
Nicotine gum is a type of chewing gum that delivers nicotine to the body. It is used as an aid in nicotine replacement therapy (NRT), a process for smoking cessation and quitting smokeless tobacco. The nicotine is delivered to the bloodstream via absorption by the tissues of the mouth.
It is currently available over-the-counter in Europe, the US and elsewhere. The pieces are usually available in individual foil packages and come in various flavors. Nicotine content is usually either 2 or 4 mg of nicotine, roughly the nicotine content of 1 or 2 cigarettes, with the appropriate content and dosage depending on the smoking habits of the user. Popular brands include Nicoderm/Nicorette, Nicogum and Nicotinell. Health Medical Pharma